2017

Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg).

Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg).

Antiviral Res. 2017;144: 153-163

Golsaz-Shirazi F, Amiri MM, Farid S, Bahadori M, Bohne F, Altstetter S, Wolff L, Kazemi T, Khoshnoodi J, Hojjat-Farsangi M, Chudy M, Jeddi-Tehrani M, Protzer U, Shokri F

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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Cancer Cell. 2017;31(6): 771-789.e6

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M

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Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

Cell Mol Gastroenterol Hepatol. 2017;4(3): 339-363

Hösel M, Quasdorff M, Ringelhan M, Kashkar H, Debey-Pascher S, Sprinzl MF, Bockmann JH, Arzberger S, Webb D, von Olshausen G, Weber A, Schultze JL, Büning H, Heikenwalder M, Protzer U

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Therapeutic vaccination for chronic hepatitis B.

Therapeutic vaccination for chronic hepatitis B.

Curr Opin Virol. 2017;23: 75-81

Kosinska AD, Bauer T, Protzer U

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Novel viral and host targets to cure hepatitis B.

Novel viral and host targets to cure hepatitis B.

Curr Opin Virol. 2017;24: 38-45

Ko C, Michler T, Protzer U

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Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.

Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.

Gut. 2017;66(2): 342-351

Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow P, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Chen Q, Abastado JP, Chew V

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Lymphotoxin ? receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.

Lymphotoxin ? receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.

Gut. 2017;66(8): 1369-1381

Mejías-Luque R, Zöller J, Anderl F, Loew-Gil E, Vieth M, Adler T, Engler DB, Urban S, Browning JL, Müller A, Gerhard M, Heikenwalder M

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PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.

Hepatology. 2017;66(2): 398-415

Zhang W, Chen J, Wu M, Zhang X, Zhang M, Yue L, Li Y, Liu J, Li B, Shen F, Wang Y, Bai L, Protzer U, Levrero M, Yuan Z

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Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.

J Hepatol. 2017;66(3): 494-503

Xia Y, Carpentier A, Cheng X, Block PD, Zhao Y, Zhang Z, Protzer U, Liang TJ

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Visualizing HEV infection in human liver tissue.

Visualizing HEV infection in human liver tissue.

J Hepatol. 2017;67(3): 443-445

Protzer U

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Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro.

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro.

J Immunol Res. 2017;2017: 4828936

Xia Y, Cheng X, Blossey CK, Wisskirchen K, Esser K, Protzer U

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Analyses of HBV cccDNA Quantification and Modification.

Analyses of HBV cccDNA Quantification and Modification.

Methods Mol Biol. 2017;1540: 59-72

Xia Y, Stadler D, Ko C, Protzer U

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Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques.

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques.

Nat Commun. 2017;8(1): 2146

Burwitz BJ, Wettengel JM, Mück-Häusl MA, Ringelhan M, Ko C, Festag MM, Hammond KB, Northrup M, Bimber BN, Jacob T, Reed JS, Norris R, Park B, Moller-Tank S, Esser K, Greene JM, Wu HL, Abdulhaqq S, Webb G, Sutton WF, Klug A, Swanson T, Legasse AW, Vu TQ, Asokan A, Haigwood NL, Protzer U, Sacha JB

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Viral hepatitis: The bumpy road to animal models for HBV infection.

Viral hepatitis: The bumpy road to animal models for HBV infection.

Nat Rev Gastroenterol Hepatol. 2017;14(6): 327-328

Protzer U

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Viral hepatitis and liver cancer.

Viral hepatitis and liver cancer.

Philos Trans R Soc Lond B Biol Sci. 2017;372(1732)

Ringelhan M, McKeating JA, Protzer U

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N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

PLoS ONE. 2017;12(1): e0170419

Appelman MD, Chakraborty A, Protzer U, McKeating JA, van de Graaf SF

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Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.

Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.

PLoS ONE. 2017;12(8): e0182936

Wisskirchen K, Metzger K, Schreiber S, Asen T, Weigand L, Dargel C, Witter K, Kieback E, Sprinzl MF, Uckert W, Schiemann M, Busch DH, Krackhardt AM, Protzer U

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IFN-?-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.

IFN-?-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.

Sci Rep. 2017;7(1): 12715

Li Y, Xia Y, Han M, Chen G, Zhang D, Thasler WE, Protzer U, Ning Q

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Immune Reconstitution After HCV Clearance With Direct Antiviral Agents: Potential Consequences for Patients With HCC?

Immune Reconstitution After HCV Clearance With Direct Antiviral Agents: Potential Consequences for Patients With HCC?

Transplantation. 2017;101(5): 904-909

Werner JM, Adenugba A, Protzer U

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Control of Hepatitis B Virus by Cytokines.

Control of Hepatitis B Virus by Cytokines.

Viruses. 2017;9(1)

Xia Y, Protzer U

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Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection.

Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection.

Viruses. 2017;9(7)

Shevtsov M, Zhao L, Protzer U, van de Klundert MAA

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