Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine.

Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine.

Antivir Ther. 2015;20(8): 779-87

Geipel A, Seiz PL, Niekamp H, Neumann-Fraune M, Zhang K, Kaiser R, Protzer U, Gerlich WH, Glebe D, The HOPE consortium

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Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the "magic bullet" to kill cccDNA.

Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the "magic bullet" to kill cccDNA.

Antiviral Res. 2015;123: 193-203

Zhang E, Kosinska A, Lu M, Yan H, Roggendorf M

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Immunosurveillance of the liver by intravascular effector CD8(+) T cells.

Immunosurveillance of the liver by intravascular effector CD8(+) T cells.

Cell. 2015;161(3): 486-500

Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Ganzer L, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M

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NIK promotes tissue destruction independently of the alternative NF-?B pathway through TNFR1/RIP1-induced apoptosis.

NIK promotes tissue destruction independently of the alternative NF-?B pathway through TNFR1/RIP1-induced apoptosis.

Cell Death Differ. 2015;22(12): 2020-33

Boutaffala L, Bertrand MJ, Remouchamps C, Seleznik G, Reisinger F, Janas M, Bénézech C, Fernandes MT, Marchetti S, Mair F, Ganeff C, Hupalowska A, Ricci JE, Becher B, Piette J, Knolle P, Caamano J, Vandenabeele P, Heikenwalder M, Dejardin E

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Next Generation of Preclinical Liver Cancer Models.

Next Generation of Preclinical Liver Cancer Models.

Clin Cancer Res. 2015;21(19): 4254-6

Weber A, O'Connor T, Heikenwalder M

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Intratumor heterogeneity in hepatocellular carcinoma.

Intratumor heterogeneity in hepatocellular carcinoma.

Clin Cancer Res. 2015;21(8): 1951-61

Friemel J, Rechsteiner M, Frick L, Böhm F, Struckmann K, Egger M, Moch H, Heikenwalder M, Weber A

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Oncogenic potential of hepatitis B virus encoded proteins.

Oncogenic potential of hepatitis B virus encoded proteins.

Curr Opin Virol. 2015;14: 109-15

Ringelhan M, Protzer U

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USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

EMBO J. 2015;34(12): 1612-29

Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M

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CCL2-CCR2 Signaling in Disease Pathogenesis.

CCL2-CCR2 Signaling in Disease Pathogenesis.

Endocr Metab Immune Disord Drug Targets. 2015;15(2): 105-18

O Connor T, Borsig L, Heikenwalder M

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T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.

T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.

Gastroenterology. 2015;149(4): 1042-52

Dargel C, Bassani-Sternberg M, Hasreiter J, Zani F, Bockmann JH, Thiele F, Bohne F, Wisskirchen K, Wilde S, Sprinzl MF, Schendel DJ, Krackhardt AM, Uckert W, Wohlleber D, Schiemann M, Stemmer K, Heikenwälder M, Busch DH, Richter G, Mann M, Protzer U

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Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

Hepatology. 2015;61(1): 238-48

Seubert B, Grünwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, Heikenwalder M, Reinheckel T, Sleeman JP, Janssen KP, Knolle PA, Krüger A

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IFN-alpha-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection

IFN-alpha-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection

Hepatology. 2015;62 1: 1030A-1030A

Li Y, Xia YC, Han MF, Chen G, Thasler WE, Luo XP, Protzer U, Ning Q

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Human papilloma virus is not detectable in samples of urothelial bladder cancer in a central European population: a prospective translational study.

Human papilloma virus is not detectable in samples of urothelial bladder cancer in a central European population: a prospective translational study.

Infect Agent Cancer. 2015;10: 31

Schmid SC, Thümer L, Schuster T, Horn T, Kurtz F, Slotta-Huspenina J, Seebach J, Straub M, Maurer T, Autenrieth M, Kübler H, Retz M, Protzer U, Gschwend JE, Hoffmann D

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Tetraspanin CD63 acts as a pro-metastatic factor via ?-catenin stabilization.

Tetraspanin CD63 acts as a pro-metastatic factor via ?-catenin stabilization.

Int J Cancer. 2015;136(10): 2304-15

Seubert B, Cui H, Simonavicius N, Honert K, Schäfer S, Reuning U, Heikenwalder M, Mari B, Krüger A

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Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

J Clin Invest. 2015;125(10): 3891-903

Mu X, Español-Suñer R, Mederacke I, Affò S, Manco R, Sempoux C, Lemaigre FP, Adili A, Yuan D, Weber A, Unger K, Heikenwälder M, Leclercq IA, Schwabe RF

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Lineage fate of ductular reactions in liver injury and carcinogenesis.

Lineage fate of ductular reactions in liver injury and carcinogenesis.

J Clin Invest. 2015;125(6): 2445-57

Jörs S, Jeliazkova P, Ringelhan M, Thalhammer J, Dürl S, Ferrer J, Sander M, Heikenwalder M, Schmid RM, Siveke JT, Geisler F

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Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.

Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.

J Hepatol. 2015;62(4): 863-70

Sprinzl MF, Puschnik A, Schlitter AM, Schad A, Ackermann K, Esposito I, Lang H, Galle PR, Weinmann A, Heikenwälder M, Protzer U

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RNAi-BASED GENE THERAPY FOR CHRONIC HEPATITIS B: EVALUATION IN A MURINE MODEL

RNAi-BASED GENE THERAPY FOR CHRONIC HEPATITIS B: EVALUATION IN A MURINE MODEL

J Hepatol. 2015;62 2: S526-S526

Michler T, Grosse S, Mockenhaupt S, Heikenwaelder M, Grimm D, Protzer U

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BISPECIFIC ANTIBODY CONSTRUCTS MEDIATE SPECIFIC RETARGETING TOWARDS AND ELIMINATION OF HBV-POSITIVE HEPATOCYTES AND TUMOR CELLS

BISPECIFIC ANTIBODY CONSTRUCTS MEDIATE SPECIFIC RETARGETING TOWARDS AND ELIMINATION OF HBV-POSITIVE HEPATOCYTES AND TUMOR CELLS

J Hepatol. 2015;62 2: S555-S556

Bohne F, Hasreiter J, Quitt O, Bockmann JH, Momburg F, Protzer U

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Decades after recovery from hepatitis B and HBsAg clearance the CD8+ T cell response against HBV core is nearly undetectable.

Decades after recovery from hepatitis B and HBsAg clearance the CD8+ T cell response against HBV core is nearly undetectable.

J Hepatol. 2015;63(1): 13-9

Kefalakes H, Jochum C, Hilgard G, Kahraman A, Bohrer AM, El Hindy N, Heinemann FM, Verheyen J, Gerken G, Roggendorf M, Timm J

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The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.

The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.

J Pathol. 2015;235(2): 355-67

Ringelhan M, O'Connor T, Protzer U, Heikenwalder M

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Molecular signatures reveal a novel HLA-B(star)15-restricted CD8 T cell epitope on the large hepatitis delta antigen

Molecular signatures reveal a novel HLA-B(star)15-restricted CD8 T cell epitope on the large hepatitis delta antigen

J Viral Hepat. 2015;22 2: 109-109

Karimzadeh H, Heinold A, Budeus B, Kosinska A, Buti M, Rizzetto M, Hoffmann D, Protzer U, Roggendorf M

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Bispecific antibody constructs mediate specific retargeting towards and elimination of HBV-positive hepatocytes and tumor cells

Bispecific antibody constructs mediate specific retargeting towards and elimination of HBV-positive hepatocytes and tumor cells

J Viral Hepat. 2015;22 2: 8-8

Bohne FM, Hasreiter J, Quitt O, Bockmann JH, Momburg F, Protzer U

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Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro.

Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro.

J Virol. 2015;89(14): 7433-8

Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R

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An Aptamer against the Matrix Binding Domain on the Hepatitis B Virus Capsid Impairs Virion Formation.

An Aptamer against the Matrix Binding Domain on the Hepatitis B Virus Capsid Impairs Virion Formation.

J Virol. 2015;89(18): 9281-7

Orabi A, Bieringer M, Geerlof A, Bruss V

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Alteration of Mature Nucleocapsid and Enhancement of Covalently Closed Circular DNA Formation by Hepatitis B Virus Core Mutants Defective in Complete-Virion Formation.

Alteration of Mature Nucleocapsid and Enhancement of Covalently Closed Circular DNA Formation by Hepatitis B Virus Core Mutants Defective in Complete-Virion Formation.

J Virol. 2015;89(19): 10064-72

Cui X, Luckenbaugh L, Bruss V, Hu J

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Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways.

Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways.

J Virol. 2015;89(5): 2698-709

Thiele F, Tao S, Zhang Y, Muschaweckh A, Zollmann T, Protzer U, Abele R, Drexler I

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KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification.

KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification.

J Virol. 2015;90(2): 930-46

Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T, Schreiner S

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Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1/Pre-S2/S vaccine.

Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1/Pre-S2/S vaccine.

Med Microbiol Immunol (Berl). 2015;204(1): 57-68

Shouval D, Roggendorf H, Roggendorf M

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Mouse models for therapeutic vaccination against hepatitis B virus.

Mouse models for therapeutic vaccination against hepatitis B virus.

Med Microbiol Immunol (Berl). 2015;204(1): 95-102

Dembek C, Protzer U

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Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation.

Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation.

Mod Pathol. 2015;28(4): 523-32

Protzer U, Böhm F, Longerich T, Seebach J, Heidary Navid M, Friemel J, Marques-Maggio E, Bawohl M, Heikenwalder M, Schirmacher P, Dutkowski P, Clavien PA, Schemmer P, Schnitzler P, Gotthardt D, Müllhaupt B, Weber A

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shRNA Sense Strand Neutralization Reduces Off-Targeting, Ameliorates Toxicity and Enhances Efficacy of RNAi-Based HBV Gene Therapy

shRNA Sense Strand Neutralization Reduces Off-Targeting, Ameliorates Toxicity and Enhances Efficacy of RNAi-Based HBV Gene Therapy

Mol Ther. 2015;23 1: S278-S278

Michler T, Grosse S, Mockenhaupt S, Protzer U, Grimm D

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Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Nat Cell Biol. 2015;17(10): 1370

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J

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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Nat Cell Biol. 2015;17(9): 1205-17

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J

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Functional classification of memory CD8(+) T cells by CX3CR1 expression.

Functional classification of memory CD8(+) T cells by CX3CR1 expression.

Nat Commun. 2015;6: 8306

Böttcher JP, Beyer M, Meissner F, Abdullah Z, Sander J, Höchst B, Eickhoff S, Rieckmann JC, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch DH, Protzer U, Thimme R, Mann M, Kurts C, Schultze JL, Kastenmüller W, Knolle PA

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A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

Nat Genet. 2015;47(1): 47-56

Rad R, Rad L, Wang W, Strong A, Ponstingl H, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Öllinger R, Zukowska M, Barenboim M, Maresch R, Cadiñanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, Ten Hoeve J, Prosser H, Seidler B, Bauer J, Heikenwälder M, Metzakopian E, Krug A, Ehmer U, Schneider G, Knösel T, Rümmele P, Aust D, Grützmann R, Pilarsky C, Ning Z, Wessels L, Schmid RM, Quail MA, Vassiliou G, Esposito I, Liu P, Saur D, Bradley A

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Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.

Nat Immunol. 2015;16(12): 1235-44

Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E

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Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.

Nat Med. 2015;21(10): 1163-71

Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT

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Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?

Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?

Nat Rev Gastroenterol Hepatol. 2015;12(10): 558-9

Protzer U

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Potential impact of human papilloma virus on survival of basaloid squamous carcinoma of the head and neck.

Potential impact of human papilloma virus on survival of basaloid squamous carcinoma of the head and neck.

Oncotarget. 2015;6(5): 3462-70

Jacobi C, Ayx I, Fritsche K, Piontek G, Hoffmann D, Weirich G, Knopf A

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Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T-cell phenotype.

Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T-cell phenotype.

Parasite Immunol. 2015;37(2): 97-104

Loffredo-Verde E, Abdel-Aziz I, Albrecht J, El-Guindy N, Yacob M, Solieman A, Protzer U, Busch DH, Layland LE, Prazeres da Costa CU

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CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.

Proc Natl Acad Sci U S A. 2015;112(45): 13982-7

Weber J, Öllinger R, Friedrich M, Ehmer U, Barenboim M, Steiger K, Heid I, Mueller S, Maresch R, Engleitner T, Gross N, Geumann U, Fu B, Segler A, Yuan D, Lange S, Strong A, de la Rosa J, Esposito I, Liu P, Cadiñanos J, Vassiliou GS, Schmid RM, Schneider G, Unger K, Yang F, Braren R, Heikenwälder M, Varela I, Saur D, Bradley A, Rad R

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Towards Autotrophic Tissue Engineering: Photosynthetic Biomaterials for Tissue Regeneration

Towards Autotrophic Tissue Engineering: Photosynthetic Biomaterials for Tissue Regeneration

Tissue Eng Part A. 2015;21 1: S85-S85

Rosas MNC, Schenck TL, Hopfner U, Centeno C, Machens HG, Somlai-Schweiger I, Heikenwalder M, Bono MR, Schwarz C, Nickelsen J, Allende ML, Egana JT

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Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways.

Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways.

Viruses. 2015;7(9): 4854-72

Wimmer P, Schreiner S

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