?4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets.

?4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets.

Acta Neuropathol Commun. 2014;2: 27

Rothhammer V, Muschaweckh A, Gasteiger G, Petermann F, Heink S, Busch DH, Heikenwälder M, Hemmer B, Drexler I, Korn T

more

Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent manner.

Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent manner.

AIDS. 2014;28(15): 2189-200

Chiozzini C, Collacchi B, Nappi F, Bauer T, Arenaccio C, Tripiciano A, Longo O, Ensoli F, Cafaro A, Ensoli B, Federico M

more

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.

Blood. 2014;124(9): 1393-403

Boettcher S, Gerosa RC, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz MG

more

Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression.

Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression.

Br J Cancer. 2014;110(3): 686-94

Wyler L, Napoli CU, Ingold B, Sulser T, Heikenwälder M, Schraml P, Moch H

more

Metabolic Activation of Intrahepatic CD8(+) T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes.

Metabolic Activation of Intrahepatic CD8(+) T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes.

Cancer Cell. 2014;26(4): 549-64

Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M

more

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.

Cardiovasc Res. 2014;103(2): 206-16

Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N

more

LINE(1)s of Evidence in HBV-Driven Liver Cancer.

LINE(1)s of Evidence in HBV-Driven Liver Cancer.

Cell Host Microbe. 2014;15(3): 249-50

Heikenwalder M, Protzer U

more

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.

Cell Rep. 2014;7(6): 1796-808

Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ

more

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.

Cell Rep. 2014;9(4): 1292-305

Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J

more

Modeling human liver cancer heterogeneity: virally induced transgenic models and mouse genetic models of chronic liver inflammation.

Modeling human liver cancer heterogeneity: virally induced transgenic models and mouse genetic models of chronic liver inflammation.

Curr Protoc Pharmacol. 2014;67: 14.31.1-14.31.17

Ringelhan M, Reisinger F, Yuan D, Weber A, Heikenwalder M

more

The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.

The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.

Cytokine Growth Factor Rev. 2014;25(2): 125-37

Seleznik GM, Zoller J, O'Connor T, Graf R, Heikenwalder M

more

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis.

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis.

EMBO Mol Med. 2014;6(8): 1062-74

Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T

more

Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo.

Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo.

Hepatology. 2014;59(6): 2110-20

Hösel M, Lucifora J, Michler T, Holz G, Gruffaz M, Stahnke S, Zoulim F, Durantel D, Heikenwalder M, Nierhoff D, Millet R, Salvetti A, Protzer U, Büning H

more

Monoclonal antibodies to various epitopes of hepatitis B surface antigen inhibit hepatitis B virus infection.

Monoclonal antibodies to various epitopes of hepatitis B surface antigen inhibit hepatitis B virus infection.

J Gastroenterol Hepatol. 2014;29(5): 1083-91

Golsaz Shirazi F, Mohammadi H, Amiri MM, Singethan K, Xia Y, Bayat AA, Bahadori M, Rabbani H, Jeddi-Tehrani M, Protzer U, Shokri F

more

Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance.

Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance.

J Hepatol. 2014;61(3): 600-8

Schölzel K, Schildberg FA, Welz M, Börner C, Geiger S, Kurts C, Heikenwälder M, Knolle PA, Wohlleber D

more

Multiple Factors Contribute to the Peripheral Induction of Cerebral ?-Amyloidosis.

Multiple Factors Contribute to the Peripheral Induction of Cerebral ?-Amyloidosis.

J Neurosci. 2014;34(31): 10264-10273

Eisele YS, Fritschi SK, Hamaguchi T, Obermüller U, Füger P, Skodras A, Schäfer C, Odenthal J, Heikenwalder M, Staufenbiel M, Jucker M

more

Hepatitis B virus-specific T-cell responses during IFN administration in a small cohort of chronic hepatitis B patients under nucleos(t)ide analogue treatment.

Hepatitis B virus-specific T-cell responses during IFN administration in a small cohort of chronic hepatitis B patients under nucleos(t)ide analogue treatment.

J Viral Hepat. 2014;21(9): 633-41

Sprinzl MF, Russo C, Kittner J, Allgayer S, Grambihler A, Bartsch B, Weinmann A, Galle PR, Schuchmann M, Protzer U, Bauer T

more

[Specific degradation of nuclear hepatitis B virus covalently closed circular DNA].

[Specific degradation of nuclear hepatitis B virus covalently closed circular DNA].

Med Sci (Paris). 2014;30(8-9): 724-6

Lucifora J, Xia Y, Reisinger F, Stadler D, Heikenwälder M, Protzer U

more

Analysis of chromosomal aberrations in murine HCC.

Analysis of chromosomal aberrations in murine HCC.

Methods Mol Biol. 2014;1193: 213-26

Unger K, Heikenwälder M

more

C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation.

C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation.

Mucosal Immunol. 2014;7(6): 1452-66

Waldschmitt N, Berger E, Rath E, Sartor RB, Weigmann B, Heikenwalder M, Gerhard M, Janssen KP, Haller D

more

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation.

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation.

Nat Immunol. 2014;15(11): 1079-89

Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V

more

Inflammatory chemokines and metastasis--tracing the accessory.

Inflammatory chemokines and metastasis--tracing the accessory.

Oncogene. 2014;33(25): 3217-24

Borsig L, Wolf MJ, Roblek M, Lorentzen A, Heikenwalder M

more

The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor.

The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor.

PLoS ONE. 2014;9(1): e87487

Helfer M, Koppensteiner H, Schneider M, Rebensburg S, Forcisi S, Müller C, Schmitt-Kopplin P, Schindler M, Brack-Werner R

more

In vivo image analysis of BoHV-4-based vector in mice.

In vivo image analysis of BoHV-4-based vector in mice.

PLoS ONE. 2014;9(4): e95779

Franceschi V, Stellari FF, Mangia C, Jacca S, Lavrentiadou S, Cavirani S, Heikenwalder M, Donofrio G

more

Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.

Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.

PLoS ONE. 2014;9(5): e96533

Wuestenberg A, Kah J, Singethan K, Sirma H, Keller AD, Rosal SR, Schrader J, Loscher C, Volz T, Bartenschlager R, Lohmann V, Protzer U, Dandri M, Lohse AW, Tiegs G, Sass G

more

Aqueous extracts of the marine brown alga Lobophora variegata inhibit HIV-1 infection at the level of virus entry into cells.

Aqueous extracts of the marine brown alga Lobophora variegata inhibit HIV-1 infection at the level of virus entry into cells.

PLoS ONE. 2014;9(8): e103895

Kremb S, Helfer M, Kraus B, Wolff H, Wild C, Schneider M, Voolstra CR, Brack-Werner R

more

HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression.

HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression.

PLoS ONE. 2014;9(8): e105478

Nehls J, Koppensteiner H, Brack-Werner R, Floss T, Schindler M

more

Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.

Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.

Retrovirology. 2014;11: 1

Koppensteiner H, Höhne K, Gondim MV, Gobert FX, Widder M, Gundlach S, Heigele A, Kirchhoff F, Winkler M, Benaroch P, Schindler M

more

HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans.

HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans.

Sci Transl Med. 2014;6(242): 242ra81

Bohne F, Londoño MC, Benítez C, Miquel R, Martínez-Llordella M, Russo C, Ortiz C, Bonaccorsi-Riani E, Brander C, Bauer T, Protzer U, Jaeckel E, Taubert R, Forns X, Navasa M, Berenguer M, Rimola A, Lozano JJ, Sánchez-Fueyo A

more

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

Science. 2014;343(6176): 1221-8

Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U

more

Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".

Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".

Science. 2014;344(6189): 1237

Xia Y, Lucifora J, Reisinger F, Heikenwalder M, Protzer U

more

New pharmacological strategies to fight enveloped viruses.

New pharmacological strategies to fight enveloped viruses.

Trends Pharmacol Sci. 2014;35(9): 470-478

Wisskirchen K, Lucifora J, Michler T, Protzer U

more

Mutational profiling of the variability of individual amino acid positions in the hepatitis B virus matrix domain.

Mutational profiling of the variability of individual amino acid positions in the hepatitis B virus matrix domain.

Virology. 2014;458-459: 183-9

Schittl B, Bruss V

more

HIV-1 Vpu mediated downregulation of CD155 requires alanine residues 10, 14 and 18 of the transmembrane domain.

HIV-1 Vpu mediated downregulation of CD155 requires alanine residues 10, 14 and 18 of the transmembrane domain.

Virology. 2014;464-465: 375-84

Bolduan S, Reif T, Schindler M, Schubert U

more

Analysis of determinants in filovirus glycoproteins required for tetherin antagonism.

Analysis of determinants in filovirus glycoproteins required for tetherin antagonism.

Viruses. 2014;6(4): 1654-71

Gnirß K, Fiedler M, Krämer-Kühl A, Bolduan S, Mittler E, Becker S, Schindler M, Pöhlmann S

more