Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.

Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.

BMC Microbiol. 2012;12: 307

Zhang D, Dong P, Zhang K, Deng L, Bach C, Chen W, Li F, Protzer U, Ding H, Zeng C

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Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.

Cancer Cell. 2012;22(1): 91-105

Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M

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Follicular dendritic cells emerge from ubiquitous perivascular precursors.

Follicular dendritic cells emerge from ubiquitous perivascular precursors.

Cell. 2012;150(1): 194-206

Krautler NJ, Kana V, Kranich J, Tian Y, Perera D, Lemm D, Schwarz P, Armulik A, Browning JL, Tallquist M, Buch T, Oliveira-Martins JB, Zhu C, Hermann M, Wagner U, Brink R, Heikenwalder M, Aguzzi A

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TNF-induced target cell killing by CTL activated through cross-presentation.

TNF-induced target cell killing by CTL activated through cross-presentation.

Cell Rep. 2012;2(3): 478-87

Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA

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Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.

Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.

Chromosoma. 2012;121(4): 353-67

Nagel J, Gross B, Meggendorfer M, Preiss C, Grez M, Brack-Werner R, Dietzel S

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Lymphotoxin, NF-?B, and cancer: the dark side of cytokines.

Lymphotoxin, NF-?B, and cancer: the dark side of cytokines.

Dig Dis. 2012;30(5): 453-68

Bauer J, Namineni S, Reisinger F, Zöller J, Yuan D, Heikenwälder M

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Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.

Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.

Gastroenterology. 2012;142(7): 1447-1450.e3

Huang LR, Gäbel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U

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Lymphotoxin ? receptor signaling promotes development of autoimmune pancreatitis.

Lymphotoxin ? receptor signaling promotes development of autoimmune pancreatitis.

Gastroenterology. 2012;143(5): 1361-74

Seleznik GM, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, Sun LK, Regenass S, Lech M, Anders HJ, McHugh D, Kumagi T, Hiasa Y, Lackner C, Haybaeck J, Angst E, Perren A, Balmer ML, Slack E, Macpherson A, Manz MG, Weber A, Browning JL, Arkan MC, Rülicke T, Aguzzi A, Prinz M, Graf R, Heikenwalder M

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Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.

Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.

Gut. 2012;61(3): 427-38

Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP

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Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

Hepatology. 2012;55(1): 287-97

Hösel M, Broxtermann M, Janicki H, Esser K, Arzberger S, Hartmann P, Gillen S, Kleeff J, Stabenow D, Odenthal M, Knolle P, Hallek M, Protzer U, Büning H

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Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice.

Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice.

Hepatology. 2012;56(3): 873-83

Stross L, Günther J, Gasteiger G, Asen T, Graf S, Aichler M, Esposito I, Busch DH, Knolle P, Sparwasser T, Protzer U

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Sorafenib modulates tumor associated macrophages and enhances anti-cancer NK cell responses

Sorafenib modulates tumor associated macrophages and enhances anti-cancer NK cell responses

Hepatology. 2012;56 1: 629A-629A

Sprinzl MartinF, Reisinger Florian, Hartmann Daniel, Friess Helmut, Weinmann Arndt, Schuchmann Marcus, Otto Gerd, Galle PeterR, Heikenwaelder Mathias, Protzer Ulrike

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Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients.

Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients.

Infect Genet Evol. 2012;12(2): 461-6

Hoffmann D, Hutzenthaler M, Seebach J, Panning M, Umgelter A, Menzel H, Protzer U, Metzler D

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Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.

Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.

J Cancer Res Clin Oncol. 2012;138(5): 843-58

Heindl S, Eggenstein E, Keller S, Kneissl J, Keller G, Mutze K, Rauser S, Gasteiger G, Drexler I, Hapfelmeier A, Höfler H, Luber B

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Longitudinal changes in HIV-1-specific T-cell quality associated with viral load dynamic.

Longitudinal changes in HIV-1-specific T-cell quality associated with viral load dynamic.

J Clin Virol. 2012;55(2): 114-20

Dembek CJ, Kutscher S, Allgayer S, Russo C, Bauer T, Hoffmann D, Goebel FD, Bogner JR, Erfle V, Protzer U, Cosma A

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Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells.

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells.

J Immunol. 2012;188(12): 5824-8

Boettcher S, Ziegler P, Schmid MA, Takizawa H, van Rooijen N, Kopf M, Heikenwalder M, Manz MG

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A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses.

A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses.

J Immunol Methods. 2012;375(1-2): 46-56

Malnati MS, Heltai S, Cosma A, Reitmeir P, Allgayer S, Glashoff RH, Liebrich W, Vardas E, Imami N, Westrop S, Nozza S, Tambussi G, Buttò S, Fanales-Belasio E, Ensoli B, Ensoli F, Tripiciano A, Fortis C, Lusso P, Poli G, Erfle V, Holmes H

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A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.

A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.

J Infect Dis. 2012;205(11): 1654-64

Krepstakies M, Lucifora J, Nagel CH, Zeisel MB, Holstermann B, Hohenberg H, Kowalski I, Gutsmann T, Baumert TF, Brandenburg K, Hauber J, Protzer U

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Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients.

Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients.

J Natl Cancer Inst. 2012;104(23): 1796-807

Chew V, Tow C, Huang C, Bard-Chapeau E, Copeland NG, Jenkins NA, Weber A, Lim KH, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP

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Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.

Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.

J Virol. 2012;86(18): 10112-22

Schneider M, Ackermann K, Stuart M, Wex C, Protzer U, Schätzl HM, Gilch S

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Design of therapeutic vaccines: hepatitis B as an example.

Design of therapeutic vaccines: hepatitis B as an example.

Microb Biotechnol. 2012;5(2): 270-82

Kutscher S, Bauer T, Dembek C, Sprinzl M, Protzer U

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Living in the liver: hepatic infections.

Living in the liver: hepatic infections.

Nat Rev Immunol. 2012;12(3): 201-13

Protzer U, Maini MK, Knolle PA

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Endothelial chemokine receptors as facilitators of tumor cell extravasation?

Endothelial chemokine receptors as facilitators of tumor cell extravasation?

Oncotarget. 2012;3(9): 919-20

Hoos A, Wolf MJ, Bauer J, Borsig L, Heikenwalder M

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Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells.

Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells.

PLoS ONE. 2012;7(1): e30054

Diem O, Schäffner M, Seifarth W, Leib-Mösch C

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Salmonella transiently reside in luminal neutrophils in the inflamed gut.

Salmonella transiently reside in luminal neutrophils in the inflamed gut.

PLoS ONE. 2012;7(4): e34812

Loetscher Y, Wieser A, Lengefeld J, Kaiser P, Schubert S, Heikenwalder M, Hardt WD, Stecher B

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Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes.

Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes.

PLoS Pathog. 2012;8(8): e1002867

O'Connor T, Frei N, Sponarova J, Schwarz P, Heikenwalder M, Aguzzi A

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Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.

Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.

Proc Natl Acad Sci U S A. 2012;109(16): 6259-64

Attems J, Alpar A, Spence L, McParland S, Heikenwalder M, Uhlén M, Tanila H, Hökfelt TG, Harkany T

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Macrophages and their relevance in Human Immunodeficiency Virus Type I infection.

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection.

Retrovirology. 2012;9: 82

Koppensteiner H, Brack-Werner R, Schindler M

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Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.

Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.

Vaccine. 2012;30(32): 4757-61

Braeckman T, Van Herck K, Jilg W, Bauer T, Van Damme P

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Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.

Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.

Vaccine. 2012;30(42): 6034-9

Farag MM, Tedjokusumo R, Flechtenmacher C, Asen T, Stremmel W, Müller M, Protzer U, Weigand K

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HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects.

HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects.

Virus Res. 2012;163(1): 380-4

Ghiglione Y, Rodríguez AM, De Candia C, Carobene M, Benaroch P, Schindler M, Salomón H, Turk G

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