Canonical NF-?B signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

Hepatology. 2016;63(5): 1592-607

Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, Müllhaupt B, Terracciano L, Gul S, Wissel S, Leithäuser F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, Hüser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwälder M

Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein.

Gut. 2016;65(3): 512-23

Sautto GA, Wisskirchen K, Clementi N, Castelli M, Diotti RA, Graf J, Clementi M, Burioni R, Protzer U, Mancini N

Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration.

Biomaterials. 2016;75(): 25-36

Chávez MN, Schenck TL, Hopfner U, Centeno-Cerdas C, Somlai-Schweiger I, Schwarz C, Machens HG, Heikenwälder M, Bono MR, Allende ML, Nickelsen J, Egaña JT

The lymphotoxin ? receptor is a potential therapeutic target in renal inflammation.

Kidney Int. 2016;89(1): 113-26

Seleznik G, Seeger H, Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwälder M, Segerer S

Herpes simplex virus in bronchoalveolar lavage fluid of medical intensive care unit patients: Association with lung injury and outcome.

J Crit Care. 2016;32(): 138-44

Saugel B, Jakobus J, Huber W, Hoffmann D, Holzapfel K, Protzer U, Schmid RM, Umgelter A

Interferon-? and Tumor Necrosis Factor-? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.

Gastroenterology. 2016;150(1): 194-205

Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwälder M, Protzer U

Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation.

Oncogene. 2016;35(24): 3178-89

Berscheminski J, Brun J, Speiseder T, Wimmer P, Ip WH, Terzic M, Dobner T, Schreiner S

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.

Hepatology. 2016;63(6): 1888-99

Matter MS, Marquardt JU, Andersen JB, Quintavalle C, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quagliata L, Elloumi F, Hoang T, Molinolo A, Conner EA, Weber A, Heikenwalder M, Factor VM, Thorgeirsson SS

Serious outbreak of human metapneumovirus in patients with hematologic malignancies.

Leuk Lymphoma. 2016;57(3): 623-7

Hoellein A, Hecker J, Hoffmann D, Göttle F, Protzer U, Peschel C, Götze K

Lentiviral hepatitis B pseudotype entry requires sodium taurocholate co-transporting polypeptide and additional hepatocyte-specific factors.

J Gen Virol. 2016;97(1): 121-7

Meredith LW, Hu K, Cheng X, Howard CR, Baumert TF, Balfe P, van de Graaf KF, Protzer U, McKeating JA

Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding.

Neoplasia. 2016;18(1): 49-59

Roblek M, Strutzmann E, Zankl C, Adage T, Heikenwälder M, Atlic A, Weis R, Kungl A, Borsig L

Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice.

Vaccine. 2016;34(7): 923-32

Backes S, Jäger C, Dembek CJ, Kosinska AD, Bauer T, Stephan AS, Di?lers A, Mutwiri G, Busch DH, Babiuk LA, Gasteiger G, Protzer U

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.

Nat Commun. 2016;7(): 10770

Maresch R, Mueller S, Veltkamp C, Öllinger R, Friedrich M, Heid I, Steiger K, Weber J, Engleitner T, Barenboim M, Klein S, Louzada S, Banerjee R, Strong A, Stauber T, Gross N, Geumann U, Lange S, Ringelhan M, Varela I, Unger K, Yang F, Schmid RM, Vassiliou GS, Braren R, Schneider G, Heikenwälder M, Bradley A, Saur D, Rad R

Intracellular transport and egress of hepatitis B virus.

J Hepatol. 2016;64(1 Suppl): S49-59

Blondot ML, Bruss V, Kann M

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment.

Immunity. 2016;44(4): 901-12

Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwälder M, Kalinke U, Prinz M

Attacking hepatitis B virus cccDNA - The holy grail to hepatitis B cure.

J Hepatol. 2016;64(1 Suppl): S41-8

Lucifora J, Protzer U

Real-time, portable genome sequencing for Ebola surveillance.

Nature. 2016;530(7589): 228-32

Quick J, Loman NJ, Duraffour S, Simpson JT, Severi E, Cowley L, Bore JA, Koundouno R, Dudas G, Mikhail A, Ouédraogo N, Afrough B, Bah A, Baum JH, Becker-Ziaja B, Boettcher JP, Cabeza-Cabrerizo M, Camino-Sánchez Á, Carter LL, Doerrbecker J, Enkirch T, García-Dorival I, Hetzelt N, Hinzmann J, Holm T, Kafetzopoulou LE, Koropogui M, Kosgey A, Kuisma E, Logue CH, Mazzarelli A, Meisel S, Mertens M, Michel J, Ngabo D, Nitzsche K, Pallasch E, Patrono LV, Portmann J, Repits JG, Rickett NY, Sachse A, Singethan K, Vitoriano I, Yemanaberhan RL, Zekeng EG, Racine T, Bello A, Sall AA, Faye O, Faye O, Magassouba N, Williams CV, Amburgey V, Winona L, Davis E, Gerlach J, Washington F, Monteil V, Jourdain M, Bererd M, Camara A, Somlare H, Camara A, Gerard M, Bado G, Baillet B, Delaune D, Nebie KY, Diarra A, Savane Y, Pallawo RB, Gutierrez GJ, Milhano N, Roger I, Williams CJ, Yattara F, Lewandowski K, Taylor J, Rachwal P, Turner DJ, Pollakis G, Hiscox JA, Matthews DA, O'Shea MK, Johnston AM, Wilson D, Hutley E, Smit E, Di Caro A, Wölfel R, Stoecker K, Fleischmann E, Gabriel M, Weller SA, Koivogui L, Diallo B, Keïta S, Rambaut A, Formenty P, Günther S, Carroll MW

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.

Nat Immunol. 2016;17(5): 593-603

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwälder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL

NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.

Nature. 2016;531(7593): 253-7

Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwälder M, Greten TF

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance.

Leukemia. 2016;30(7): 1520-30

Spinner S, Crispatzu G, Yi JH, Munkhbaatar E, Mayer P, Höckendorf U, Müller N, Li Z, Schader T, Bendz H, Hartmann S, Yabal M, Pechloff K, Heikenwalder M, Kelly GL, Strasser A, Peschel C, Hansmann ML, Ruland J, Keller U, Newrzela S, Herling M, Jost PJ

Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line.

FEBS J. 2016;283(9): 1669-88

Broecker F, Hardt C, Herwig R, Timmermann B, Kerick M, Wunderlich A, Schweiger MR, Borsig L, Heikenwälder M, Lehrach H, Moelling K

Validation of an IFN?/IL2 FluoroSpot assay for clinical trial monitoring.

J Transl Med. 2016;14(1): 175

Körber N, Behrends U, Hapfelmeier A, Protzer U, Bauer T

Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.

EMBO Mol Med. 2016;8(9): 1082-98

Michler T, Große S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Ko C, Heikenwälder M, Protzer U, Grimm D

New findings in HCV genotype distribution in selected West European, Russian and Israeli regions.

J Clin Virol. 2016;81(): 82-9

Kartashev V, Döring M, Nieto L, Coletta E, Kaiser R, Sierra S, HCV EuResist Study group , Guerrero A, Stoiber H, Paar C, Vandamme AM, Van Ranst M, Nevens F, Cuypers L, Braun P, Ehret R, Obermeier M, Schneeweiss S, Scholten S, Römer K, Isernhagen K, Qurashi N, Heger E, Knops E, Neumann-Fraune M, Timm J, Walker A, Lübke N, Wedemeyer H, Schulze Zur Wiesch J, Lütgehetmann M, Polywka S, Däumer M, Hoffmann D, Protzer U, Marascio N, Foca A, Liberto MC, Barreca GS, Galati L, Torti C, Pisani V, Perno CF, Ceccherini-Silberstein F, Cento V, Ciotti M, Zazzi M, Rossetti B, De Luca A, Caudai C, Mor O, Devaux C, Staub T, Araújo F, Gomes P, Cabanas J, Markin N, Khomenko I, Govorukhina M, Lugovskaya G, Dontsov D, Mas A, Martró E, Saludes V, Rodríguez-Frías F, Garcia F, Casas P, de la Iglesia A, Alados JC, Pena-López MJ, Rodríguez MJ, Galán JC, Suarez A, Cardeñoso L, Guerrero MD, Vegas-Dominguez C, Blas-Espada J, Garcia R, Garcia-Bujalance S, Benítez-Gutiérrez L, de Mendoza C, Montiel N, Santos J, Viciana I, Delgado A, Martínez-Sanchez PA, Fernández-Alonso M, Reina G, Trigo M, Echeverría MJ, Aguilera A, Navarro D, Bernal S, Lozano MC, Fernández-Cuenca F, Orduña A, Eiros JM, Ortízde Lejarazu R, Martínez-Sapiña AM, García-Díaz A, Haque T

Single-Dose Hepatitis A Immunization: 7.5-Year Observational Pilot Study in Nicaraguan Children to Assess Protective Effectiveness and Humoral Immune Memory Response.

J Infect Dis. 2016;214(10): 1498-1506

Mayorga O, Bühler S, Jaeger VK, Bally S, Hatz C, Frösner G, Protzer U, van Damme P, Egger M, Herzog C

"To Be or Not to Be": Immune Tolerance in Chronic Hepatitis B.

Gastroenterology. 2016;151(5): 805-806

Protzer U, Knolle P

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.

Hepatology. 2016;64(3): 746-59

Thomsen MK, Nandakumar R, Stadler D, Malo A, Valls RM, Wang F, Reinert LS, Dagnaes-Hansen F, Hollensen AK, Mikkelsen JG, Protzer U, Paludan SR

Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

MedChemComm. 2016;7(9): 1797-1801

Lehmann J, Vomacka J, Esser K, Nodwell M, Kolbe K, Ramer P, Protzer U, Reiling N, Sieber SA