Publikationen

Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle.

Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle.

Antiviral Res. 2018;151: 4-7

Esser K, Lucifora J, Wettengel J, Singethan K, Glinzer A, Zernecke A, Protzer U

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Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination.

Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination.

Curr Opin Virol. 2018;30: 58-67

Dembek C, Protzer U, Roggendorf M

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Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry.

Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry.

Drugs Aging. 2018;35(9): 843-857

Dultz G, Müller T, Petersen J, Mauss S, Zimmermann T, Muche M, Simon KG, Berg T, Zeuzem S, Hüppe D, Böker K, Wedemeyer H, Welzel TM, Leberstiftungs-GmbH Deutschland , Günther R, Hinrichsen H, Heyne R, Roth J, Goeser T, Ullrich R, John C, Hofmann WP, Teuber G, Möller H, Baumgarten A, Schwenzer J, Pathil A, Kraus MR, Weber A, Jung MC, Gerken G, Antoni C, Doss MF, Schober A, Hoffstadt M, Lucadou AV, Steffens H, Klinker H, Geier A, Klausen G, Buggisch P, Cornberg M, Sarrazin C, Manns MP, Niederau C, Protzer U, Schirmacher P

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The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.

The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.

Genes (Basel). 2018;9(10)

Velkov S, Ott JJ, Protzer U, Michler T

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Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Hepatology. 2018;68(6): 2089-2105

Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D

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Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.

J Hepatol. 2018;69(6): 1231-1241

Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U

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Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines.

Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines.

J Innate Immun. 2018;10(4): 339-348

Faure-Dupuy S, Vegna S, Aillot L, Dimier L, Esser K, Broxtermann M, Bonnin M, Bendriss-Vermare N, Rivoire M, Passot G, Lesurtel M, Mabrut JY, Ducerf C, Salvetti A, Protzer U, Zoulim F, Durantel D, Lucifora J

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Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8 T Cells.

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8 T Cells.

J Virol. 2018;92(13)

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M

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One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors.

One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors.

Mol Ther Nucleic Acids. 2018;12: 242-253

Schiwon M, Ehrke-Schulz E, Oswald A, Bergmann T, Michler T, Protzer U, Ehrhardt A

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Single cell polarity in liquid phase facilitates tumour metastasis.

Single cell polarity in liquid phase facilitates tumour metastasis.

Nat Commun. 2018;9(1): 887

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M

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The hepatitis B epidemic and the urgent need for cure preparedness.

The hepatitis B epidemic and the urgent need for cure preparedness.

Nat Rev Gastroenterol Hepatol. 2018;15(9): 517-518

Lazarus JV, Block T, Bréchot C, Kramvis A, Miller V, Ninburg M, Pénicaud C, Protzer U, Razavi H, Thomas LA, Wallace J, Cowie BC

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Hepatitis B virus promotes ?-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.

Hepatitis B virus promotes ?-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.

Oncotarget. 2018;9(74): 33947-33960

von Olshausen G, Quasdorff M, Bester R, Arzberger S, Ko C, van de Klundert M, Zhang K, Odenthal M, Ringelhan M, Niessen CM, Protzer U

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Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg).

Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg).

Antiviral Res. 2017;144: 153-163

Golsaz-Shirazi F, Amiri MM, Farid S, Bahadori M, Bohne F, Altstetter S, Wolff L, Kazemi T, Khoshnoodi J, Hojjat-Farsangi M, Chudy M, Jeddi-Tehrani M, Protzer U, Shokri F

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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Cancer Cell. 2017;31(6): 771-789.e6

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M

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Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

Cell Mol Gastroenterol Hepatol. 2017;4(3): 339-363

Hösel M, Quasdorff M, Ringelhan M, Kashkar H, Debey-Pascher S, Sprinzl MF, Bockmann JH, Arzberger S, Webb D, von Olshausen G, Weber A, Schultze JL, Büning H, Heikenwalder M, Protzer U

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Therapeutic vaccination for chronic hepatitis B.

Therapeutic vaccination for chronic hepatitis B.

Curr Opin Virol. 2017;23: 75-81

Kosinska AD, Bauer T, Protzer U

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Novel viral and host targets to cure hepatitis B.

Novel viral and host targets to cure hepatitis B.

Curr Opin Virol. 2017;24: 38-45

Ko C, Michler T, Protzer U

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Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.

Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.

Gut. 2017;66(2): 342-351

Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow P, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Chen Q, Abastado JP, Chew V

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Lymphotoxin ? receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.

Lymphotoxin ? receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.

Gut. 2017;66(8): 1369-1381

Mejías-Luque R, Zöller J, Anderl F, Loew-Gil E, Vieth M, Adler T, Engler DB, Urban S, Browning JL, Müller A, Gerhard M, Heikenwalder M

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PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.

Hepatology. 2017;66(2): 398-415

Zhang W, Chen J, Wu M, Zhang X, Zhang M, Yue L, Li Y, Liu J, Li B, Shen F, Wang Y, Bai L, Protzer U, Levrero M, Yuan Z

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Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.

J Hepatol. 2017;66(3): 494-503

Xia Y, Carpentier A, Cheng X, Block PD, Zhao Y, Zhang Z, Protzer U, Liang TJ

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Visualizing HEV infection in human liver tissue.

Visualizing HEV infection in human liver tissue.

J Hepatol. 2017;67(3): 443-445

Protzer U

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Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro.

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro.

J Immunol Res. 2017;2017: 4828936

Xia Y, Cheng X, Blossey CK, Wisskirchen K, Esser K, Protzer U

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Analyses of HBV cccDNA Quantification and Modification.

Analyses of HBV cccDNA Quantification and Modification.

Methods Mol Biol. 2017;1540: 59-72

Xia Y, Stadler D, Ko C, Protzer U

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Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques.

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques.

Nat Commun. 2017;8(1): 2146

Burwitz BJ, Wettengel JM, Mück-Häusl MA, Ringelhan M, Ko C, Festag MM, Hammond KB, Northrup M, Bimber BN, Jacob T, Reed JS, Norris R, Park B, Moller-Tank S, Esser K, Greene JM, Wu HL, Abdulhaqq S, Webb G, Sutton WF, Klug A, Swanson T, Legasse AW, Vu TQ, Asokan A, Haigwood NL, Protzer U, Sacha JB

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Viral hepatitis: The bumpy road to animal models for HBV infection.

Viral hepatitis: The bumpy road to animal models for HBV infection.

Nat Rev Gastroenterol Hepatol. 2017;14(6): 327-328

Protzer U

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Viral hepatitis and liver cancer.

Viral hepatitis and liver cancer.

Philos Trans R Soc Lond B Biol Sci. 2017;372(1732)

Ringelhan M, McKeating JA, Protzer U

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N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

PLoS ONE. 2017;12(1): e0170419

Appelman MD, Chakraborty A, Protzer U, McKeating JA, van de Graaf SF

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Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.

Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.

PLoS ONE. 2017;12(8): e0182936

Wisskirchen K, Metzger K, Schreiber S, Asen T, Weigand L, Dargel C, Witter K, Kieback E, Sprinzl MF, Uckert W, Schiemann M, Busch DH, Krackhardt AM, Protzer U

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IFN-?-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.

IFN-?-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.

Sci Rep. 2017;7(1): 12715

Li Y, Xia Y, Han M, Chen G, Zhang D, Thasler WE, Protzer U, Ning Q

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Immune Reconstitution After HCV Clearance With Direct Antiviral Agents: Potential Consequences for Patients With HCC?

Immune Reconstitution After HCV Clearance With Direct Antiviral Agents: Potential Consequences for Patients With HCC?

Transplantation. 2017;101(5): 904-909

Werner JM, Adenugba A, Protzer U

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Control of Hepatitis B Virus by Cytokines.

Control of Hepatitis B Virus by Cytokines.

Viruses. 2017;9(1)

Xia Y, Protzer U

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Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection.

Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection.

Viruses. 2017;9(7)

Shevtsov M, Zhao L, Protzer U, van de Klundert MAA

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